Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma.

摘要: The t(14;18) translocation, which involves the bcl-2 oncogene, occurs in follicular lymphomas (FL) at two common sites: major breakpoint region ( MBR ) and minor cluster mcr ). biological clinical significance of these breakpoints is unknown. site was determined 247 previously untreated patients (49% men; median age 52 years) with indolent FL (155 grade I, 83 II, 8 III) to correlate it pretreatment characteristics, response, outcome. by a polymerase chain reaction method peripheral blood (all cases), bone marrows (149 fresh lymph node biopsy specimens (68 cases). occurred 175 cases (71%) 27 (11%). In 45 (18%), no detected (germline). No significant relationship found between rearrangements expression BLC-2 BAX proteins. Patients’ germline for tended present more frequently stage IV disease higher β2-microglobulin (β2M) levels, whereas -rearranged presented early normal β2M. complete response rate significantly lower than that patients. An estimated 3-year failure-free survival (FFS) , MBR, 95%, 76%, 57%, respectively P  < .001). independent serum β2M lactate dehydrogenase its correlation FFS. conclusion, rearrangement an important prognostic factor FL, useful identify who may require different treatment.