Association of sleep apnea with clinically silent microvascular brain tissue changes in acute cerebral ischemia.

摘要: The aim of this study was to determine the importance sleep apnea in relation clinically silent microvascular brain tissue changes patients with acute cerebral ischemia. Patients ischemia prospectively underwent nocturnal respiratory polygraphy within 5 days from symptom-onset. Sleep defined as apnea–hypopnea-index (AHI) ≥5/h. Experienced readers blinded clinical and sleep-related data reviewed computed tomography magnetic resonance imaging scans for leukoaraiosis chronic lacunar infarctions. Ischemic lesions were considered when did not recall associated stroke-like symptoms. Functional outcome assessed modified Rankin Scale at discharge, 6 12 months. Fifty-one 56 (91 %) had any degree. moderate-to-severe (Wahlund score ≥5) found have higher mean AHI than those none or mild (34.4 vs. 12.8/h, p < 0.001). Moderate-to-severe (AHI ≥15/h) be an independent predictor (adjusted OR 6.03, 95 % CI 1.76–20.6, = 0.0042) infarctions 10.5, 2.19–50.6, 0.003). Wahlund AHI, more likely unfavorable functional resulted over time (p 0.0373). In ischemia, is may negatively influence outcome. Routine screening further investigation possible long-term effects non-invasive ventilatory treatment appear warranted at-risk population.