Associations of sleep-disordered breathing and cerebral changes on MRI.

摘要: STUDY OBJECTIVES Population-based studies have demonstrated associations between sleep-disordered breathing (SDB), hypertension, and cardiovascular disease; few large-scale examined of SDB with objective measures cerebrovascular disease. This study tested the significance evidence brain injury or ischemia determined by cerebral magnetic resonance imaging (MRI) studies. DESIGN Cross-sectional longitudinal analyses in a nested sample Cardiovascular Health Study participants Sleep Heart Study. PARTICIPANTS The 843 individuals (mean age 77, SD 4.3 years, 58% women) who had MRI as part before after polysomnography obtained MEASUREMENTS A 12-channel polysomnogram was used to derive indexes breathing. Repeated measurements provided infarct (presence size) white matter Logistic regression were model changes infarct-like lesions disease function age, baseline grade, central obstructive RESULTS Individuals showed progression compared those did not significantly more likely show Cheyne-Stokes respiration pattern an increased number but apneas. CONCLUSIONS An association change grade sleep apnea that consistent causal pathway which contributes alternatively, may be marker subclinical