Biological effect of intermittent radiation exposure in vivo: Recovery from sublethal damage versus reoxygenation
作者： Natsuo Tomita , Yuta Shibamoto , Masato Ito , Hiroyuki Ogino , Chikao Sugie
DOI: 10.1016/J.RADONC.2007.08.007
关键词:
摘要: Purpose: In vivo effects of intermittent irradiation are influenced by recovery from sublethal damage (SLDR) and reoxygenation, so contribution the two factors were investigated using murine tumors. Methods materials: 1-cm-diameter SCCVII tumors growing in legs C3H/HeN mice used. First, 5 fractions 6 Gy given at intervals 2.5‐15 min compared an vivo‐in vitro assay, clamping tumor-bearing to exclude influence reoxygenation. second third experiments, changes hypoxic fraction 0‐15 after 13 or assessed a paired cell survival method. Fourth, 3‐10 under conditions limited reoxygenation growth delay assay. Results: Cell clamped tended increase with elongation intervals, but not significantly. The decrease 5‐15 level immediately irradiation. Effects on tumor intervals. Conclusions: Reoxygenation occurring within appeared compensate for SLDR When was limited, radiation effect occurred due SLDR. c 2007 Elsevier Ireland Ltd. All rights reserved. Radiotherapy Oncology 86 (2008) 369–374.
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sci-hub.se 参考文章(23)
Yutaka Yukawa, Masaji Takahashi, Kazushige Tsutsui, Mitsuyuki Abe, Yuta Shibamoto, Variation in the hypoxic fraction among mouse tumors of different types, sizes, and sites Japanese Journal of Cancer Research. ,vol. 77, pp. 908- 915 ,(1986) , 10.20772/CANCERSCI1985.77.9_908
David J. Chaplin, Peggy L. Olive, Ralph E. Durand, Intermittent Blood Flow in a Murine Tumor: Radiobiological Effects Cancer Research. ,vol. 47, pp. 597- 601 ,(1987)
Antje Ernst-Stecken, Oliver Ganslandt, Ulrike Lambrecht, Rolf Sauer, Gerhard Grabenbauer, Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: results and toxicity. Radiotherapy and Oncology. ,vol. 81, pp. 18- 24 ,(2006) , 10.1016/J.RADONC.2006.08.024
Il Han Kim, J. Martin Brown, Reoxygenation and rehypoxiation in the SCCVII mouse tumor International Journal of Radiation Oncology Biology Physics. ,vol. 29, pp. 493- 497 ,(1994) , 10.1016/0360-3016(94)90444-8
Yuta Shibamoto, Yoshizumi Kitakabu, Rumi Murata, Natsuo Oya, Toru Shibata, Keisuke Sasai, Masaji Takahashi, Mitsuyuki Abe, Reoxygenation in the SCCVII tumor after KU-2285 sensitization plus single or fractionated irradiation International Journal of Radiation Oncology Biology Physics. ,vol. 29, pp. 583- 586 ,(1994) , 10.1016/0360-3016(94)90461-8
Mary J. Dorie, Robert F. Kallman, Reoxygenation in the RIF-1 tumor. International Journal of Radiation Oncology Biology Physics. ,vol. 10, pp. 687- 693 ,(1984) , 10.1016/0360-3016(84)90300-6
D.J. Chaplin, R.E. Durand, P.L. Olive, Acute hypoxia in tumors: Implications for modifiers of radiation effects International Journal of Radiation Oncology Biology Physics. ,vol. 12, pp. 1279- 1282 ,(1986) , 10.1016/0360-3016(86)90153-7
M. M. ELKIND, T. ALESCIO, R. W. SWAIN, W. B. MOSES, H. SUTTON, RECOVERY OF HYPOXIC MAMMALIAN CELLS FROM SUB-LETHAL X-RAY DAMAGE. Nature. ,vol. 202, pp. 1190- 1193 ,(1964) , 10.1038/2021190A0
Robert F. Kallman, The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology. ,vol. 105, pp. 135- 142 ,(1972) , 10.1148/105.1.135
Yuta Shibamoto, Masato Ito, Chikao Sugie, Hiroyuki Ogino, Masaki Hara, Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and imrt International Journal of Radiation Oncology*Biology*Physics. ,vol. 59, pp. 1484- 1490 ,(2004) , 10.1016/J.IJROBP.2004.04.039