Reoxygenation in the SCCVII tumor after KU-2285 sensitization plus single or fractionated irradiation

摘要: Abstract Purpose : Because reoxygenation of solid tumors after irradiation with a hypoxic cell sensitizer has never previously been investigated, we assessed the in SCCVII treatment KU-2285 plus single or fractionated irradiation. Methods and Materials (100 mg/kg) was injected intraperitoneally into C3H mice bearing 1-cm at 30 min before dose 12 Gy three fractions 5 h intervals. Changes fraction (HF) were then evaluated by paired survival curve method. Results Since radiosensitizing effect relatively persistent, HF only evaluable 6 The untreated 9.1%. After Gy, 25% h, 32% 24% 24 7.6% 72 h. lower than that radiation alone, but similar later periods. without KU-2285, 33% both groups, while it 12% 13% for pretreated those receiving respectively. However, sensitizing indicated downward shift curves irradiated exposure to this agent. Conclusion Reoxygenation occurred quite efficiently Gy. irradiation, however, KU-2285-pretreatment alone groups.