BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis

作者: Bernd Kaina , Kirsten Ochs , Sabine Grösch , Gerhard Frizz , Jochen Lips

DOI: 10.1016/S0079-6603(01)68088-7

关键词:

摘要: … Therefore, killing resistance is not entirely a linear function of the number of MGMT molecules per cell, especially in the high-dose range. Obviously, with high doses of an SN1 agent, …

参考文章(46)
Bruce Chabner, Jerry M. Collins, Cancer Chemotherapy: Principles and Practice ,(1990)
Mark R. Kelley, Adly Yacoub, Walter A. Deutsch, The DNA Repair Activity of Human Redox/Repair Protein APE/Ref-1 Is Inactivated by Phosphorylation Cancer Research. ,vol. 57, pp. 5457- 5459 ,(1997)
Bernd Kaina, Sabine Grösch, Gerhard Fritz, Apurinic Endonuclease (Ref-1) Is Induced in Mammalian Cells by Oxidative Stress and Involved in Clastogenic Adaptation Cancer Research. ,vol. 58, pp. 4410- 4416 ,(1998)
L J Walker, C N Robson, E Black, D Gillespie, I D Hickson, Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Molecular and Cellular Biology. ,vol. 13, pp. 5370- 5376 ,(1993) , 10.1128/MCB.13.9.5370
A J Fornace, B Zmudzka, M C Hollander, S H Wilson, Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells. Molecular and Cellular Biology. ,vol. 9, pp. 851- 853 ,(1989) , 10.1128/MCB.9.2.851
A. Klungland, L. Fairbairn, A.J. Watson, G.P. Margison, E. Seeberg, Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents. The EMBO Journal. ,vol. 11, pp. 4439- 4444 ,(1992) , 10.1002/J.1460-2075.1992.TB05544.X
Bernd Kaina, Gerhard Fritz, Kirsten Ochs, Simone Haas, Thomas Grombacher, Jörg Dosch, Markus Christmann, Per Lund, Cornelia M Gregel, Klaus Becker, Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms. Mutation Research. ,vol. 405, pp. 179- 191 ,(1998) , 10.1016/S0027-5107(98)00135-3