Circular dumbbell decoy oligodeoxynucleotides (cdodn) containing dna bindings sites of transcription

作者: Ryuichi Morishita , In-Kyu Lee

DOI:

关键词:

摘要: The present invention provides a circular dumbbell oligodeoxynucleotide (CDODN) comprising two loop structures and stem structure, wherein the structure comprises nucleotide sequence capable of binding DNA-binding domain transcriptional factor. further pharmaceutical composition said CDODN. can be used for treating and/or preventing disease or disorder related to such also method factor, administering subject therapeutically effective amount CDODN

参考文章(113)
A W Clowes, M A Reidy, M M Clowes, Mechanisms of stenosis after arterial injury. Laboratory Investigation. ,vol. 49, pp. 208- 215 ,(1983)
D A Brown, S H Kang, S M Gryaznov, L DeDionisio, O Heidenreich, S Sullivan, X Xu, M I Nerenberg, Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. Journal of Biological Chemistry. ,vol. 269, pp. 26801- 26805 ,(1994) , 10.1016/S0021-9258(18)47090-1
William R. Pearson, Using the FASTA Program to Search Protein and DNA Sequence Databases Methods of Molecular Biology. ,vol. 24, pp. 307- 331 ,(1994) , 10.1385/0-89603-246-9:307
M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, G. Draetta, Cyclin A is required at two points in the human cell cycle. The EMBO Journal. ,vol. 11, pp. 961- 971 ,(1992) , 10.1002/J.1460-2075.1992.TB05135.X
D. Callsen, B. Brune, A. Von Knethen, Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression. Journal of Immunology. ,vol. 163, pp. 2858- 2866 ,(1999)
Yoon S. Cho-Chung, Yun Gyu Park, Maria Nesterova, Youl Nam Lee, Yee Sook Cho, CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth. Molecular and Cellular Biochemistry. ,vol. 212, pp. 29- 34 ,(2000) , 10.1023/A:1007144618589
R.J. Davis, The mitogen-activated protein kinase signal transduction pathway. Journal of Biological Chemistry. ,vol. 268, pp. 14553- 14556 ,(1993) , 10.1016/S0021-9258(18)82362-6
Alessandra Romanelli, Carlo Pedone, Michele Saviano, Nicoletta Bianchi, Monica Borgatti, Carlo Mischiati, Roberto Gambari, Molecular interactions with nuclear factor κB (NF‐κB) transcription factors of a PNA–DNA chimera mimicking NF‐κB binding sites FEBS Journal. ,vol. 268, pp. 6066- 6075 ,(2001) , 10.1046/J.0014-2956.2001.02549.X