Nucleic acid-containing composition, its preparation and use

作者: Didier Bazile , Gilles Spenlehauer , Claude Helene , Carole Emile

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摘要: Compositions including nucleic acids and cationic oligopeptides capable of forming secondary structures, their use in therapeutics gene therapy, particular for transferring into cells, are disclosed.

参考文章(17)
Brett P. Monia, Susan M. Freier, David J. Ecker, ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE. ,(1992)
Matthew Dr Cotten, Max L Prof Dr Birnstiel, Ernst Dr Wagner, New protein-polycation conjugates. ,(1991)
E. Wagner, M. Cotten, R. Foisner, M. L. Birnstiel, Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 4255- 4259 ,(1991) , 10.1073/PNAS.88.10.4255
Bernard Barbier, Andre Brack, Conformation-controlled hydrolysis of polyribonucleotides by sequential basic polypeptides Journal of the American Chemical Society. ,vol. 114, pp. 3511- 3515 ,(1992) , 10.1021/JA00035A053
Ramon Eritja, Anna Pons, Mónica Escarcellar, Ernest Giralt, Fernando Albericio, Synthesis of defined peptide-oligonucleotide hybrids containing a nuclear transport signal sequence. Tetrahedron. ,vol. 47, pp. 4113- 4120 ,(1991) , 10.1016/S0040-4020(01)86448-6
Hartmut Dr. Beug, Matthew Dr. Cotten, Ernst Dr. Wagner, Max L. Prof. Dr. Birnstiel, Protein-polycation conjugates ,(1990)
A. M. Gewirtz, C. A. Stein, P. M. Glazer, FACILITATING OLIGONUCLEOTIDE DELIVERY : HELPING ANTISENSE DELIVER ON ITS PROMISE Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 3161- 3163 ,(1996) , 10.1073/PNAS.93.8.3161
R. Mulligan, The basic science of gene therapy Science. ,vol. 260, pp. 926- 932 ,(1993) , 10.1126/SCIENCE.8493530
Xiaohuai Zhou, Aleksander L. Klibanov, Leaf Huang, Lipophilic polylysines mediate efficient DNA transfection in mammalian cells. Biochimica et Biophysica Acta. ,vol. 1065, pp. 8- 14 ,(1991) , 10.1016/0005-2736(91)90003-Q