Application Potential of Engineered Liposomes in Tumor Targeting

摘要: Most anticancer agents are poorly water soluble and highly potent by nature, leading to nonselective devastation of tumor, as well normal healthy cells; this poses an obstinate challenge in safe effective tumor chemotherapy. To get the better debilitating problem, liposomes have emerged revolutionary cargoes, last few decades, with successful rates on rise targeting. Their extraordinary capability carry both hydrophilic hydrophobic bioactives separate domains residence amenability surface compositional engineering destine vesicular system come true “magic bullet concept” which was enunciated great biologist Paul Ehrlich. Enhanced permeability retention effect specific ligands mediate passive targeting active tumors, respectively. The stealth attributed PEGylation has opened up new horizons prolonged drug delivery, proved be a promising tactic solve safety issues associated principles. Current scenarios fabrication techniques bring forth environmentally responsive features (pH, temperature, photosensitivity, etc.) facilitate enhanced localization at site, addition capabilities. This chapter sums potential engineered liposomes, contemporary trends field liposomal research.