Controlling the location and activation of Rab GTPases

摘要: The remarkable degree of specificity with which Rab GTPases recognise distinct subsets intracellular membranes forms the basis their ability to act as key cellular regulators, determining recruitment downstream effectors right membrane at time. molecular mechanisms controlling localisation, however, have proved tricky issues address. It is becoming increasingly apparent that multiple factors contribute localisation and close coordination targeting activation. With important new insights into mode action general regulators REP RabGDI, well demonstration novel such Yip3/Pra1 GDI displacement signals within proteins specificity, a better understanding concepts governing function now beginning emerge. diversity processes regulated by family members made possible, not only wide range they recruit, but also different regulating own