Modification of alpha-adrenoceptor agonist antinociceptive activity by nisoxetine: a selective inhibitor of noradrenergic uptake.
作者： Martin D. Hynes , John K. Henderson
DOI: 10.1016/0091-3057(84)90286-7
关键词:
摘要: The alpha-adrenoceptor agonists, clonidine and xylazine, produced a dose-dependent antinociceptive effect in the mouse writhing assay as does morphine. Fluoxetine, highly-specific inhibitor of serotonin uptake, enhanced morphine this test but not that or xylazine. In contrast, nisoxetine, selective noradrenergic significantly potentiated activity morphine, clonidine, These findings strengthen evidence for an involvement mechanism effects agonists.
elsevier.com
sci-hub.se 参考文章(35)
Harbans Lal, Stuart Fielding, Psychopharmacology of clonidine A.R. Liss. ,(1981)
R.D.E. Sewell, P.S.J. Spencer, 5 The Role of Biogenic Agents in the Actions of Centrally-Acting Analgesics Progress in Medicinal Chemistry. ,vol. 14, pp. 249- 283 ,(1977) , 10.1016/S0079-6468(08)70150-4
J L Maderdrut, T L Yaksh, S V Reddy, Spinal cord pharmacology of adrenergic agonist-mediated antinociception. Journal of Pharmacology and Experimental Therapeutics. ,vol. 213, pp. 525- 533 ,(1980)
B B Molloy, F P Bymaster, D T Wong, J S Horng, A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine. Journal of Pharmacology and Experimental Therapeutics. ,vol. 193, pp. 804- 811 ,(1975)
Gudrun Paalzow, Lennart Paalzow, Clonidine antinociceptive activity: effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 292, pp. 119- 126 ,(1976) , 10.1007/BF00498581
F. Cankat Tulunay, Ichiro Yano, A.E. Takemori, The effect of biogenic amine modifiers on morphine analgesia and its antagonism by naloxone European Journal of Pharmacology. ,vol. 35, pp. 285- 292 ,(1976) , 10.1016/0014-2999(76)90230-2
Tony L. Yaksh, Jim C. DuChateau, Thomas A. Rudy, Antagonism by methysergide and cinanserin of the antinociceptive action of morphine administered into the periaqueductal gray. Brain Research. ,vol. 104, pp. 367- 372 ,(1976) , 10.1016/0006-8993(76)90634-X
C. G. SPARKES, P. S. J. SPENCER, Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat. British Journal of Pharmacology. ,vol. 42, pp. 230- 241 ,(1971) , 10.1111/J.1476-5381.1971.TB07104.X
C. T. MAJOR, BARBARA J. PLEUVRY, Effects of α‐methyl‐p‐tyrosine, p‐chlorophenylalanine, l‐β‐(3,4‐dihydroxyphenyl)alanine, 5‐hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse British Journal of Pharmacology. ,vol. 42, pp. 512- 521 ,(1971) , 10.1111/J.1476-5381.1971.TB07137.X
David T. Wong, Frank P. Bymaster, Effect of nisoxetine on uptake of catecholamines in synaptosomes isolated from discrete regions of rat brain. Biochemical Pharmacology. ,vol. 25, pp. 1979- 1983 ,(1976) , 10.1016/0006-2952(76)90053-8