5 The Role of Biogenic Agents in the Actions of Centrally-Acting Analgesics

摘要: Publisher Summary This chapter discusses the interactions of opiates with central (and peripheral) neuronal transmitters such as noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT) acetylclioline (ACh), and histamine, to understand subcellular actions morphine better. The extent which various properties centrally acting analgesics can be explained in terms alterations functional state NA, DA, 5-HT, ACh histamine. A fuller appreciation morphine-like agents biogenic amines is important for a number reasons. First, it may help identify components spectrum sub-cellular that exerts so enable new obtained specific properties. Secondly, prove possible those are involved tolerance physical dependence. differences exist between clonidine-like demonstrated by acute intracerebroventricular (ICV) injection amines, NA rodents, this technique promises more rapid economic method demonstrating or non-morphinelike analgesic than resorting long-term studies primates.