STUDIES OF ANALGESIC DRUGS. VIII. A NARCOTIC ANTAGONIST ANALGESIC WITHOUT PSYCHOTOMIMETIC EFFECTS.

摘要: The effects of 29-hydroxy-5,9-dimethyl-2-(3,3-dimethylallyl)-6,7-benzomorphan (Win 20,228) a weak narcotic antagonist, have been studied in man. In the treatment postoperative pain 10-20 mg/70 kg Win 20,228 produced analgesia equivalent to 10 morphine. degree respiratory depression by 20 was comparable that subjective were qualitatively and quantitatively similar those Except for one patient who reported "crazy thoughts," nalorphine-like psychotomimetic not observed other patients or healthy subjects. shown be antagonist morphine induced antagonized potent antagonists. contrast morphine, doses greater than 2 mg/kg intravenously tachycardia hypertension. may represent first clinically useful analgesic with minimal addiction liability.