Structure homology and interaction redundancy for discovering virus–host protein interactions
作者： Benoît de Chassey , Laurène Meyniel‐Schicklin , Anne Aublin‐Gex , Vincent Navratil , Thibaut Chantier
关键词:
摘要: Virus–host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction such is, however, technically challenging time consuming. Here we describe an original method for the prediction high-confidence interactions between viral human proteins through a combination structure high-quality interactome data. Validation was performed NS1 protein influenza virus, which led identification host factors that control replication.
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