Estimation of age and rate of increase of rare variants.

作者: Thompson Ea

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摘要: Abstract The problem considered is that of estimating the age or rate increase a variant on basis present number replicates observed in population. In place previous diffusion equation analyses probability distributions, likelihood for studied discrete branching process model. It shown variations inherent gene evolution natural populations make it impossible to provide reliable point estimate specified variant, although analysis provides confidence interval which may useful bounds period originated. The distribution numbers several variants also information. problems estimation are discussed with reference rare arising American Indian populations.

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