Acute and chronic nicotine effects on behaviour and brain activation during intertemporal decision making

摘要: Previous studies demonstrated higher discount rates for delayed rewards in smokers than non-smokers. We performed this study to determine whether those differences intertemporal choice are due pharmacological effects of nicotine and track related brain regions. Thirty-three non-smokers 27 nicotine-dependent underwent functional magnetic resonance imaging while performing an task consisting 40 sets monetary reward options that varied by delay delivery. Smokers were investigated a state satiation. Non-smokers twice, receiving (2 mg) placebo gums double-blinded, randomized cross-over design. displayed steeper temporal discounting Those behavioural reflected the response during decision between two alternative money/time pairs: showed less activation parietal occipital areas (e.g. precuneus) under placebo. A single dose led similar effect on but did not impact behaviour. Processing magnitude pairs differed non-smokers: decreased reactivity ventral striatum. Moreover, there was acute processing magnitude: increased correlation blood oxygen level-dependent mean amount left hippocampus, amygdala anterior insula. conclude cross-sectional only, part, nicotine. Longitudinal needed investigate pre-drug group characteristics as well consequences smoking behaviour its neural correlates.