Cognitive mechanisms of nicotine on visual attention.
作者： Natalia S Lawrence , Thomas J Ross , Elliot A Stein
DOI: 10.1016/S0896-6273(02)01004-8
关键词: Cognition 、 Posterior parietal cortex 、 Thalamus 、 Psychology 、 Brain mapping 、 Neuroscience 、 Cortex (anatomy) 、 Addiction 、 Nicotine 、 Arousal
摘要: Understanding nicotine's neurobiological and cognitive mechanisms may help explain both its addictive properties potential therapeutic applications. As such, functional MRI was used to determine the neural substrates of effects on a sustained attention (rapid visual information-processing) task. Performance associated with activation in fronto-parietal-thalamic network smokers nonsmokers. Along subtle behavioral deficits, mildly abstinent showed less task-induced brain parietal cortex caudate than did Transdermal nicotine replacement improved task performance increased cortex, thalamus, caudate, while induced generalized increase occipital activity. These data suggest that improves by enhancing areas traditionally attention, arousal, motor activation.
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Philip J Bushnell, Edward D Levin, Richard T Marrocco, Martin F Sarter, Barbara J Strupp, David M Warburton, Attention as a target of intoxication: insights and methods from studies of drug abuse. Neurotoxicology and Teratology. ,vol. 22, pp. 487- 502 ,(2000) , 10.1016/S0892-0362(00)00077-5
M. A. H. Russell, J. Peto, U. A. Patel, The Classification of Smoking by Factorial Structure of Motives Journal of the Royal Statistical Society, Series A. Methodical. ,vol. 137, pp. 313- 333 ,(1974) , 10.2307/2344953
Verner Knott, Melissa Bosman, Collen Mahoney, Vadim Ilivitsky, Kevin Quirt, Transdermal Nicotine: Single Dose Effects on Mood, EEG, Performance, and Event-Related Potentials Pharmacology, Biochemistry and Behavior. ,vol. 63, pp. 253- 261 ,(1999) , 10.1016/S0091-3057(99)00006-4
D LaBerge, MS Buchsbaum, Positron emission tomographic measurements of pulvinar activity during an attention task The Journal of Neuroscience. ,vol. 10, pp. 613- 619 ,(1990) , 10.1523/JNEUROSCI.10-02-00613.1990
M Corbetta, FM Miezin, S Dobmeyer, GL Shulman, SE Petersen, Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography The Journal of Neuroscience. ,vol. 11, pp. 2383- 2402 ,(1991) , 10.1523/JNEUROSCI.11-08-02383.1991
G Aston-Jones, J Rajkowski, P Kubiak, T Alexinsky, Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task The Journal of Neuroscience. ,vol. 14, pp. 4467- 4480 ,(1994) , 10.1523/JNEUROSCI.14-07-04467.1994
J Kievit, H. Kuypers, Basal forebrain and hypothalamic connection to frontal and parietal cortex in the Rhesus monkey. Science. ,vol. 187, pp. 660- 662 ,(1975) , 10.1126/SCIENCE.1114317
LINDA RUECKERT, JORDAN GRAFMAN, Sustained attention deficits in patients with right frontal lesions. Neuropsychologia. ,vol. 34, pp. 953- 963 ,(1996) , 10.1016/0028-3932(96)00016-4
J.T Coull, R.S.J Frackowiak, C.D Frith, Monitoring for target objects: activation of right frontal and parietal cortices with increasing time on task Neuropsychologia. ,vol. 36, pp. 1325- 1334 ,(1998) , 10.1016/S0028-3932(98)00035-9
K. Wesnes, A. Revell, The separate and combined effects of scopolamine and nicotine on human information processing. Psychopharmacology. ,vol. 84, pp. 5- 11 ,(1984) , 10.1007/BF00432014