The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
作者： Hogyu David Seo , Chang Seob Kwon , Daeyoup Lee
DOI: 10.1007/S00294-017-0792-6
关键词:
摘要: Accumulating evidence shows that non-proteolytic functions of the proteasome are as crucial its well-known proteolytic function in regulating cellular activities. In our recent work, we showed 19S mediates heterochromatin spreading centromeric manner. However, involvement other regions remained largely unknown. present study, investigated role subtelomere and facultative regions. Using mutant, rpt4-1, show is involved silencing formation fission yeast. addition to this proteasome-related regulation, also observed a distinct pathway regulates through Paf1 complex subunit, Leo1. Our comparison two pathways revealed new group domains regulated exclusively by pathway. Taken together, findings reveal global regulation constitutive heterochromatin.
springer.com
sci-hub.se 参考文章(64)
Beate C. Braun, Michael Glickman, Regine Kraft, Burkhardt Dahlmann, Peter-M. Kloetzel, Daniel Finley, Marion Schmidt, The base of the proteasome regulatory particle exhibits chaperone-like activity. Nature Cell Biology. ,vol. 1, pp. 221- 226 ,(1999) , 10.1038/12043
J.M. Peters, W.W. Franke, J.A. Kleinschmidt, Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm Journal of Biological Chemistry. ,vol. 269, pp. 7709- 7718 ,(1994) , 10.1016/S0021-9258(17)37345-3
Elizabeth H. Blackburn, Telomere states and cell fates Nature. ,vol. 408, pp. 53- 56 ,(2000) , 10.1038/35040500
Robin C. Allshire, Karl Ekwall, Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe Cold Spring Harbor Perspectives in Biology. ,vol. 7, ,(2015) , 10.1101/CSHPERSPECT.A018770
Laure Verrier, Francesca Taglini, Ramon R. Barrales, Shaun Webb, Takeshi Urano, Sigurd Braun, Elizabeth H. Bayne, Global regulation of heterochromatin spreading by Leo1. Open Biology. ,vol. 5, pp. 150045- ,(2015) , 10.1098/RSOB.150045
Chang-wei Liu, Linda Millen, Tracie B. Roman, Hai Xiong, Hiram F. Gilbert, Robert Noiva, George N. DeMartino, Philip J. Thomas, Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome. Journal of Biological Chemistry. ,vol. 277, pp. 26815- 26820 ,(2002) , 10.1074/JBC.M201782200
David M. Smith, Shih-Chung Chang, Soyeon Park, Daniel Finley, Yifan Cheng, Alfred L. Goldberg, Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry Molecular Cell. ,vol. 27, pp. 731- 744 ,(2007) , 10.1016/J.MOLCEL.2007.06.033
Tyler McCann, William Tansey, Functions of the proteasome on chromatin. Biomolecules. ,vol. 4, pp. 1026- 1044 ,(2014) , 10.3390/BIOM4041026
Chase T. Archer, Lyle Burdine, Bo Liu, Anwarul Ferdous, Stephen Albert Johnston, Thomas Kodadek, Physical and Functional Interactions of Monoubiquitylated Transactivators with the Proteasome Journal of Biological Chemistry. ,vol. 283, pp. 21789- 21798 ,(2008) , 10.1074/JBC.M803075200
F. Geng, W. P. Tansey, Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 6060- 6065 ,(2012) , 10.1073/PNAS.1200854109