The taurine transporter: mechanisms of regulation.

摘要: Taurine transport undergoes an adaptive response to changes in taurine availability. Unlike most amino acids, is not metabolized or incorporated into protein but remains free the intracellular water. Most acids are reabsorbed at rates of 98-99%, reabsorption may range from 40% 99.5%. Factors that influence accumulation include ionic environment, electrochemical charge, and post-translational transcriptional factors. Among these kinase C (PKC) activation transactivation repression by proto-oncogenes such as WT1, c-Jun, c-Myb p53. Renal regulation transporter (TauT) was studied vivo vitro. Site-directed mutagenesis oocyte expression system were used study TauT PKC. Reporter genes Northern Western blots gene (TauT). We demonstrated (i) body pool controlled through renal availability; (ii) pH, developmental ontogeny accumulation; (iii) fourth segment involved gating across cell membrane, which PKC phosphorylation serine 322 level; (iv) repressed p53 tumour suppressor transactivated c-Myb; (v) over-expression protects cells cisplatin-induced nephrotoxicity.