SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain.

摘要: While novel influential concepts in neuroscience bring the focus to local activities generated within a few tens of cubic micrometers brain, we are still devoid appropriate tools record and manipulate pharmacologically neuronal activity at this fine scale. Here designed, fabricated encapsulated microprobes for simultaneous depth recording drug delivery using exclusively polymer SU-8 as structural material. A tetrode- linear-like electrode patterning was combined first time with single double fluidic microchannels independent delivery. The device tested experimentally vivo anesthetized rat preparation. Both probe types successfully recorded detailed spatiotemporal features field potentials single-cell resolution never attained before integrated probes. Drug achieved high spatial temporal precision range from nanoliters microliters, confirmed histologically. These technological advancements will foster wide neural applications aimed monitoring brain very precise micrometer