A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging.

摘要: Although the number of centenarians is growing worldwide, potential factors influencing aging process remain only partially elucidated. Researchers are increasingly focusing toward biomarkers as tools to shed more light on pathophysiology complex phenotypes, including ability reach successful aging, i.e., free major chronic diseases. We therefore conducted a case-control study examining associations multiple candidate in healthy and sex-matched elderly controls. Using 81 (aged ≥ 100 years) selected based fact that they were disease-free 46 controls 70–80 years), serum levels 15 different involved regulation metabolism, angiogenesis, inflammation, bone formation measured. Of tested, four molecules (chemerin, fetuin-A, fibroblast growth [FGF] 19 21) found be independently associated with regardless sex. Logistic regression analysis confirmed chemerin, FGF19, FGF21 [predicted probability (PP) = 1 / [1 + exp (11.832 − 0.027 × (chemerin) 0.009 (fetuin-A) 0.014 (FGF19) 0.007 (FGF21)]. The area under curve (AUC) predicted values for four-biomarker panel revealed it can discriminate between excellent accuracy (AUC > 0.94, P < 0.001). preliminary essence limited by low sample size lack replication other independent cohorts, our data suggest an association FGF21, which may provide novel information mechanisms behind human process. Whether predict deserves further scrutiny.