Models for computer simulation studies of input functions for tracer kinetic modeling with positron emission tomography
作者： Dagan Feng , Sung-Cheng Huang , Xinmin Wang
DOI: 10.1016/0020-7101(93)90049-C
关键词:
摘要: In tracer kinetic modeling with Positron Emission Tomography (PET), the direct measurement (piecewise linear approximation) of plasma time-activity curve (PTAC) is often used as input function to estimate regional physiological parameters. However, no explicit general model available for PTAC itself, which limits further study effects PTAC, such noise or sampling schedules, on parameters estimation. A proposed in this paper and compared other four possible candidates. Eight sets [18F]-fluoro-2-deoxy-D-glucose (FDG) experimental data were test models several statistical criteria validate their adequacy. An application improve estimation local cerebral metabolic rate glucose (LCMRGlc) presented. This also expected be useful generating realistic curves computer simulation studies tracers characteristics.
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