Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis

作者: Jian-Min Tang , Quan-Ying He , Rui-Xia Guo , Xiu-Jun Chang

DOI: 10.1016/J.LUNGCAN.2005.10.003

关键词:

摘要: … suppressor gene PTEN negatively regulates the PI3K/Akt … The long-term survival rate of patients remains unsatisfactory … expression patterns of the three Akt isoforms. A broadspectrum …

参考文章(42)
Ken Andre Olaussen, Jean-Charles Soria, Luc Morat, Antoine Martin, Laure Sabatier, Jean-Francois Morere, David Khayat, Jean-Philippe Spano, None, Loss of PTEN expression is not uncommon, but lacks prognostic value in stage I NSCLC. Anticancer Research. ,vol. 23, pp. 4885- 4890 ,(2003)
Antonio D. Cristofano, Barbara Pesce, Carlos Cordon-Cardo, Pier P. Pandolfi, Pten is essential for embryonic development and tumour suppression. Nature Genetics. ,vol. 19, pp. 348- 355 ,(1998) , 10.1038/1235
H-J. Su Huang, Webster K. Cavenee, Frank B. Furnari, The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells Cancer Research. ,vol. 58, pp. 5002- 5008 ,(1998)
Amy S. Clark, Peter M. Blumberg, Phillip A. Dennis, Kip A. West, Altered Protein Kinase C (PKC) Isoforms in Non-Small Cell Lung Cancer Cells: PKCδ Promotes Cellular Survival and Chemotherapeutic Resistance Cancer Research. ,vol. 63, pp. 780- 786 ,(2003)
Takahisa Takino, Masahito Tamura, Jianguo Gu, Kenneth M. Yamada, Tumor Suppressor PTEN Inhibition of Cell Invasion, Migration, and Growth: Differential Involvement of Focal Adhesion Kinase and p130Cas Cancer Research. ,vol. 59, pp. 442- 449 ,(1999)
D. R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B. A. Hemmings, Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal. ,vol. 15, pp. 6541- 6551 ,(1996) , 10.1002/J.1460-2075.1996.TB01045.X
Paul J. COFFER, Jing JIN, James R. WOODGETT, Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochemical Journal. ,vol. 335, pp. 1- 13 ,(1998) , 10.1042/BJ3350001
Masahito Tamura, Jianguo Gu, Erik H. J. Danen, Takahisa Takino, Shingo Miyamoto, Kenneth M. Yamada, PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway * Journal of Biological Chemistry. ,vol. 274, pp. 20693- 20703 ,(1999) , 10.1074/JBC.274.29.20693