Erythropoietin Pathway: A Potential Target for the Treatment of Depression

摘要: During the past decade, accumulating evidence from both clinical and experimental studies has indicated that erythropoietin may have antidepressant effects. In addition to kidney liver, many organs been identified as secretory tissues for erythropoietin, including brain. Its receptor is expressed in cerebral spinal cord neurons, hypothalamus, hippocampus, neocortex, dorsal root ganglia, nerve axons, Schwann cells. These findings highlight new functions which was originally considered play a crucial role progress of erythroid differentiation. Erythropoietin its signaling through JAK2 activate multiple downstream pathways STAT5, PI3K/Akt, NF-κB, MAPK. factors an important inflammation neuroprogression nervous system. This particularly true possibly related learning, memory, neurocognitive deficits mood alterations. Thus, influence on known be involved treatment depression makes erythropoietin-related pathway attractive target development therapeutic approaches. Focusing help us understand pathogenic mechanisms molecular basis treatment.