Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

摘要: We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome vivo. observed that fragile protein was acutely required and interacted with argonaute1 staufen formation long-term memory. Occlusion mutants could be rescued by synthesis inhibitors, suggesting excess baseline negatively affect cognition.