Disruption of structural covariance networks for language in autism is modulated by verbal ability.

摘要: The presence of widespread speech and language deficits is a core feature autism spectrum disorders (ASD). These impairments have often been attributed to altered connections between brain regions. Recent developments in anatomical correlation-based approaches map structural covariance offer an effective way studying such vivo. In this study, we employed network (SCN)-based approach investigate the integrity networks fronto-temporal brain regions twenty children with ASD compared age gender-matched control group twenty-two children. Our findings reflected large-scale disruption inter intrahemispheric left frontal SCNs controls, but no differences right SCNs. Interhemispheric left-seeded was further found be modulated by verbal ability participants irrespective diagnosis, suggesting that function might related strength interhemispheric Additionally, regional cortical thickening observed posterior regions, which predicted decreasing symptom severity increasing ASD. unify reports morphology They also suggest reduced hemisphere asymmetry increased growth may not only reflect neurodevelopmental aberrations compensatory mechanisms.