Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol

摘要: Uptake in brown adipose tissue (hibernating fat) is sometimes seen at FDG-PET examinations. Despite a characteristic appearance, this may hide clinically relevant uptake. Stimulation of the sympathetic nervous system increases glucose uptake fat. We now re-examine patients with fat activity that could disguise tumour after pre-treatment propranolol (a non-selective β-blocker) order to reduce Our first examinations kind are reported. Eleven strong were studied. There was mean 5 days (range 2–8) between At second examination, 80 mg given orally 2 h before FDG administration. In addition visual evaluation uptake, SUV assessments fat, lung, heart, liver, spleen and bone marrow made. All showed complete or almost disappearance examination (p < 0.001) both upon when comparing SUVs. seven there also known strongly suspected malignancy, which remained unchanged Beyond an insignificant decrease myocardial no redistribution various examined organs examination. Pre-treatment single dose blocks tissue, thereby increasing specificity The seems not be impaired.