Biological effects of silicone gel sheeting.

摘要: Since silicone gels were first used in the treatment of hypertrophic scars (HS) and keloids (K) they have proved useful safe. Depending on specific investigation, application showed improvements redness, itching, texture thickness HS K 60% to 100% cases. Generally, was scar characteristic change, followed by color height. Despite wide use K, many studies that been performed past 2 decades, mode action these materials remains poorly understood. This knowledge is even more difficult obtain because pathogenesis still unclear. Moreover, terms are sometimes interchangeably, making it compare results effect treatments among different studies. However, criteria differentiate recently reported, has hypothesized immunologic mechanisms could be involved development K. Furthermore, we demonstrated presence an immune cell infiltrate characterized immunophenotypic features this infiltrate, which indicative a delayed type reaction. show distinct profiles, amount related age clinical behavior HS. It reported gel softens reduces shorter period time than pressure therapy obtained not due pressure, temperature, or oxygen tension. also temperature differences less 1 C, as found under sheeting (SGS), can significant collagenase kinetics may alter scarring. Elasticity, measured elastometry, significantly increased SGS treated compared with control lesions. In recent study, investigation evaluate efficacy using objective measurements confirm subjective evaluations taking biopsies for histologic immunohistochemical analysis. Quantitative measures ultrasound perfusion laser doppler imaging. Preliminary reduction total both treatment. The mean percentage change from initial assessment highly reduction. There perfusion, although statistically significant, especially Biopsies taken patients who at baseline 12 weeks had given their consent. We observed spindle-shaped cells number lymphocytes strongly expressed CD11a/CD18 (LFA-1) adhesion molecules, suggests induced modifications appears there no release into skin after application, but definite. Silicones synthetic polymers containing repeating silicone-oxygen backbone organic groups attached directly silicon atom. Elemental starting material manufacture products. most common polymer polydimethylsiloxane (PDMS). length chain degree cross linking, differentiated classes commercial composed Hypertrophic IL-8 Interleukin-8 Keloids PDMS Polydimethylsiloxane Silicone