Investigations on the sensitivity of several biochemical and histological methods after liver intoxication induced by pentachlorophenol and carbon tetrachloride.

摘要: The connection between injury to energy metabolism, lipid peroxidation and cytotoxicity may be a target in the search for sensitive parameters detecting different types of hepatocellular damage. objective present study was define more precisely availability thiobarbituric acid (TBA) reactivity, method studying peroxidation, polarographic determination oxidative phosphorylation this field. Carbon tetrachloride (CCl4) used as an experimental model agent initiate after metabolic conversion trichloromethyl radical (Recknagel et al 1989). Pentachlorophenol (PCP) which acts uncoupler (Koch Axmann 1987) also used.