Effects of glycine antagonists on Mg2+- and glycine-induced binding
作者： Kotaro Hatta , Toshifumi Yamamoto , Takafumi Hori , Masao Okuwa , Takashi Moroji
DOI: 10.1016/0304-3940(92)90470-R
关键词:
摘要: Abstract We investigated the effects of glycine antagonists, 3-amino-1-hydroxy-2-pyrrolidone (HA-966), 7-chlorokynurenic acid (7-Cl-KYNA), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylic (DHQXC), 6,7-dichloroquinoxaline-2,3-dione (DCQX), and 5-chloro-indole-2-carboxylic (5-Cl-I2CA), on Mg2+- glycine-induced [ 3 H ]N-(1-[2- thienyl]cyclohexyl )-3,4- piperidine ([ H]TCP ) binding to well-washed rat cortical membranes. Except for 5-Cl-I2CA, all antagonists completely inhibited not only glycine- but also Mg2+-induced [3H]TCP in a concentration-dependent manner. Out antogonists examined DHQXC most selectively binding, while DCQX was selective inhibiting binding.
sci-hub.se 参考文章(18)
Kotaro Hatta, Toshifumi Yamamato, Takafumi Hori, Masao Okuwa, Takashi Moroji, 3-((±)2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) more potently antagonizes the high-affinity Mg2+ binding site on the receptor ion channel complex than the l-glutamate recognition site Neuroscience Letters. ,vol. 124, pp. 229- 231 ,(1991) , 10.1016/0304-3940(91)90100-8
Takafumi Hori, Toshifumi Yamamoto, Kohtaro Hatta, Takashi Moroji, Biphasic effects of magnesium on the binding in the rat cerebral cortex Neuroscience Letters. ,vol. 119, pp. 9- 11 ,(1990) , 10.1016/0304-3940(90)90742-R
B M Baron, M G Palfreyman, B L Harrison, F G Salituro, I A McDonald, H S White, C J Schmidt, S M Sorensen, F P Miller, Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site. Molecular Pharmacology. ,vol. 38, pp. 554- 561 ,(1990)
Yoel Kloog, Hadas Lamdani-Itkin, Mordechai Sokolovsky, The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid. Journal of Neurochemistry. ,vol. 54, pp. 1576- 1583 ,(1990) , 10.1111/J.1471-4159.1990.TB01207.X
Peter Frey, Daniel Berney, Paul L. Herrling, Werner Mueller, Stephan Urwyler, 6,7-Dichloro-3-hydroxy-2-quinoxalinecarboxylic acid is a relatively potent antagonist at NMDA and kainate receptors. Neuroscience Letters. ,vol. 91, pp. 194- 198 ,(1988) , 10.1016/0304-3940(88)90767-7
J. Huettner, Indole-2-Carboxylic Acid: A Competitive Antagonist of Potentiation by Glycine at the NMDA Receptor Science. ,vol. 243, pp. 1611- 1613 ,(1989) , 10.1126/SCIENCE.2467381
J.W. McDonald, J.B. Penney, M.V. Johnston, A.B. Young, Characterization and regional distribution of strychnine-insensitive [3H]glycine binding sites in rat brain by quantitative receptor autoradiography Neuroscience. ,vol. 35, pp. 653- 668 ,(1990) , 10.1016/0306-4522(90)90336-3
Domenico E. Pellegrini-Giampietro, Alessandro Galli, Marina Alesiani, Giovanna Cherici, Flavio Moroni, Quinoxalines interact with the glycine recognition site of NMDA receptors: studies in guinea-pig myenteric plexus and in rat cortical membranes. British Journal of Pharmacology. ,vol. 98, pp. 1281- 1286 ,(1989) , 10.1111/J.1476-5381.1989.TB12675.X
Kiyokazu Ogita, Yukio Yoneda, 6,7-Dichloroquinoxaline-2,3-Dione is a Competitive Antagonist Specific to Strychnine-Insensitive [3H]Glycine Binding Sites on the N-Methyl-D-Aspartate Receptor Complex Journal of Neurochemistry. ,vol. 54, pp. 699- 702 ,(1990) , 10.1111/J.1471-4159.1990.TB01927.X
William F. Hood, Robert P. Compton, Joseph B. Monahan, N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site. Journal of Neurochemistry. ,vol. 54, pp. 1040- 1046 ,(1990) , 10.1111/J.1471-4159.1990.TB02355.X