6,7-Dichloro-3-hydroxy-2-quinoxalinecarboxylic acid is a relatively potent antagonist at NMDA and kainate receptors.
作者： Peter Frey , Daniel Berney , Paul L. Herrling , Werner Mueller , Stephan Urwyler
DOI: 10.1016/0304-3940(88)90767-7
关键词:
摘要: Abstract The 6,7-dichloro derivative of 3-hydroxy-2-quinoxalinecarboxylic acid (diCl-HQC) is a relatively potent antagonist at the two excitatory amino receptor subtypes activated by N- methyl- d -aspartate (NMDA) and kainic acid. It antagonizes NMDA-induced excitation in frog spinal cord (pA2 5.8), i.e. with potency similar to -2-amino-7-phosphonoheptanoate ( -AP-7). also sodium efflux from rat brain slices 5.6). compound inhibits acid-induced pA2 5.4 it [3H]kainic binding membranes pKi 5.4. DiCl-HQC only weakly active quisqualate receptor. This spectrum activities may make this useful tool investigate pharmacology receptors.
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