Antagonist profile of 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylate at excitatory amino acid receptors in the neonatal rat spinal cord

作者: Phillip J. Birch , Carol J. Grossman , Ann G. Hayes

DOI: 10.1016/0014-2999(89)90405-6

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摘要: Abstract In the neonatal rat spinal cord, 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylate antagonised responses mediated at both N-methyl-D-asparta (NMDA) and non-NMDA receptors. The antagonism of to NMDA was unsurmountable via an antagonist action allosterically-linked strychnine-insensitive glycine site. At receptors, appeared act as a competitive low concentrations non-competitive higher concentrations. contrast published data, this did not distinguish between by DL-α⇐ino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) kainate.

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