Hyperlipoproteinaemia and atherosclerosis in rabbits fed low-level cholesterol and lecithin.

摘要: Dutch-Belted rabbits were fed for 18 months an atherogenic semipurified gel diet containing 14% hydrogenated coconut oil and 0.06% cholesterol (approximately 0.15 mg/kcal) or a non-atherogenic basal the same ingredients but with no cholesterol. Rabbits developed hypercholesterolaemia (means 733 mg/dl at 16 months) plasma lipoprotein (LP) distribution shifted from pattern in which high-density lipoproteins (HDL) predominated to one very-low-density (VLDL) predominant. Total cholesterol/triglyceride ratio d less than 1.006 LP changed 0.3 1.8. Plasma returned normal followed by plus 3% soya lecithin additional 4 months. had extensive, usually full circumference fibromuscular plaques main branches of coronary arteries all portions aorta compromised lumen area almost 50%. These lesions modified lecithin. The lacked foam cells clefts, cellular distinct fibrous surface occupied space. Animals did not develop 86 months), although slightly favour increased low-density (LDL) decreased HDL compared standard commercial diet. Basal atherosclerosis only minimal focal cell proximal aorta. Liver injury including fatty change, cholangitis portal fibrosis occurred animals Thus, appropriate diets low accumulate cholesterol-enriched their abdominal are similar those man. Also, this experimental model, dietary promotes return profile removal lipid established atherosclerotic plaque.