Calcium channels contribute to albiflorin-mediated antinociceptive effects in mouse model.
作者： Yizhi Zhang , Dejun Sun , Qingjin Meng , Wanxu Guo , Qiuhui Chen
DOI: 10.1016/J.NEULET.2016.03.054
关键词:
摘要: Albiflorin (AF), one of important bioactive constituents Paeonia lactiflora Radix, possesses neuro-protective effect. The present study aims to investigate the antinociceptive activities AF and possible mechanisms. suppressed acetic acid-caused writhing, lengthened latency period mouse in hot plate test, reduced licking biting response time injected paw during phase I II, it suggested that exerted activity mainly through central nervous system. Nimodipine, a commonly used calcium channels blocker, strongly AF-enhanced test. Compared with control group, levels euronal nitric oxide synthase (nNOS), enhanced serotonin (5-HT) serum and/or hypothalamus before after 30-s thermal stimuli. activation calmodulin-dependent protein kinase II c-Jun N-terminal was observed AF-treated mice. Collectively, AF-mediated were, at least partially, related channels.
sci-hub.se 参考文章(27)
Wan-Hung Lee, Zhili Xu, Nicole M. Ashpole, Andy Hudmon, Pushkar M. Kulkarni, Ganesh A. Thakur, Yvonne Y. Lai, Andrea G. Hohmann, Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics. Neuropharmacology. ,vol. 97, pp. 464- 475 ,(2015) , 10.1016/J.NEUROPHARM.2015.05.038
Petr M. Masliukov, Konstantin Y. Moiseev, Marina B. Korzina, Valentina V. Porseva, Development of nNOS-positive neurons in the rat sensory ganglia after capsaicin treatment Brain Research. ,vol. 1618, pp. 212- 221 ,(2015) , 10.1016/J.BRAINRES.2015.05.040
Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wang, Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats Chemico-Biological Interactions. ,vol. 242, pp. 211- 217 ,(2015) , 10.1016/J.CBI.2015.10.001
Arunava Kali, Antibiotics and Bioactive Natural Products in Treatment of Methicillin Resistant Staphylococcus aureus: A Brief Review Pharmacognosy Reviews. ,vol. 9, pp. 29- 34 ,(2015) , 10.4103/0973-7847.156329
John-Paul J. Pozek, David Beausang, Jaime L. Baratta, Eugene R. Viscusi, The Acute to Chronic Pain Transition: Can Chronic Pain Be Prevented? Medical Clinics of North America. ,vol. 100, pp. 17- 30 ,(2016) , 10.1016/J.MCNA.2015.08.005
T. Trang, R. Al-Hasani, D. Salvemini, M. W. Salter, H. Gutstein, C. M. Cahill, Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics The Journal of Neuroscience. ,vol. 35, pp. 13879- 13888 ,(2015) , 10.1523/JNEUROSCI.2711-15.2015
René De Beun, Annette Lohmann, Renate Schneider, Jean De Vry, Comparison of the stimulus properties of ethanol and the Ca2+ channel antagonist nimodipine in rats European Journal of Pharmacology. ,vol. 306, pp. 5- 13 ,(1996) , 10.1016/0014-2999(96)00198-7
Sylwia Magiera, Şefika Gülmez, Aleksandra Michalik, Irena Baranowska, Application of statistical experimental design to the optimisation of microextraction by packed sorbent for the analysis of nonsteroidal anti-inflammatory drugs in human urine by ultra-high pressure liquid chromatography. Journal of Chromatography A. ,vol. 1304, pp. 1- 9 ,(2013) , 10.1016/J.CHROMA.2013.06.047
Mamoru Ono, Tetsuo Satoh, Pharmacological studies on lappaconitine: possible interaction with endogenous noradrenergic and serotonergic pathways to induce antinociception. Japanese Journal of Pharmacology. ,vol. 58, pp. 251- 257 ,(1992) , 10.1254/JJP.58.251
T. M. Cunha, D. Roman-Campos, C. M. Lotufo, H. L. Duarte, G. R. Souza, W. A. Verri, M. I. Funez, Q. M. Dias, I. R. Schivo, A. C. Domingues, D. Sachs, S. Chiavegatto, M. M. Teixeira, J. S. Hothersall, J. S. Cruz, F. Q. Cunha, S. H. Ferreira, Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 4442- 4447 ,(2010) , 10.1073/PNAS.0914733107