Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study.

摘要: Background and purpose The role of depression in the development outcome cardiometabolic diseases remains to be clarified. We aimed examine extent which depressive symptoms affect transitions from healthy diabetes, stroke, heart disease subsequent all-cause mortality a middle-aged elderly European population. Methods A total 78 212 individuals aged ≥50 years Survey Health Ageing Retirement Europe were included. Participants with any baseline including stroke excluded. Depressive measured by Euro-Depression scale at baseline. followed up determine occurrence mortality. used multistate models estimate transition-specific HRs 95% CIs after adjustment confounders. Results During 500 711 person-years follow-up, 4742 participants developed 2173 had 5487 7182 died. significantly associated diabetes (HR: 1.12, CI: 1.05 1.20), 1.31, 1.18 1.44), 1.26, 1.34) 1.41, 1.34 1.49). After diseases, increased risk patients 1.54, 1.25 1.89), who 1.29, 1.03 1.61) 1.21, 1.02 1.44). Conclusions increase disease, onset these conditions. Screening treatment may have profound implications for prevention prognosis diseases.