Intracranial ependymomas of childhood. Lack of correlation of histopathology and clinical outcome.

摘要: Summary The histopathology of 66 children with the diagnosis ependymoma who were operated on at our institution between 1954 and 1994 reviewed. We performed an initial analysis using entire study cohort to determine which histopathological features associated each other in a statistically significant fashion attempt identify combinations that together might be useful predicting outcome. A detailed outcome was then 37 most recent cases survived postoperative period, whom pre- post-imaging studies as well long term follow-up obtained, order predictive overall progression free survival. Five- ten-year progression-free survivals 45.1% 36.1 %, respectively. Overall 57.1% 45.1%, Of eight individual features, only presence necrosis found correlate less favorable survival (PFS) (p = 0.06 0.03, respectively). In addition, combination vascular proliferation or nuclear pleomorphism worse PFS 0.01 0.02, However, when clinical factors included multivariate regression analysis, none histological independently no relationship pattern rosettes (true rosette, pseudorosette, perivascular pseudorosette) conclusion, although this association certain histo-pathological ependymomas, these relationships did not reach statistical significance and, thus, do provide sufficient evidence for modifying therapy based alone.