Analytical approaches to investigating metal-containing drugs

摘要: Abstract Many pharmaceuticals contain metals, either as part of the active compound or within formulation. They are also found in related products such dietary supplements and toiletries. Concentrations metals biological fluids tissues from patients taking these agents, measured where there may be an adverse reaction, dose-related toxicity for therapeutic drug monitoring. Other situations, analysis environmental samples include occupational exposure (manufacture, administration to patients, pharmaceutical research) investigations poisoning. Highly sensitive accurate analytical methods now available determine total metal concentration a specific sample, but measure chemical form drug, metabolite drug's interaction with important cellular components, DNA. The use ICP-MS concentrations, HPLC coupled more complex speciation measurements, will depend on type information that is required. For investigation species present, other complementary techniques electrospray mass spectrometry (LC–MS/MS) required full structural elucidation analytes. In this current publication we highlight measurement two metal(loid) based drugs treatment cancer. One 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) containing arsenic under solid tumours, second cis-diamminedichloroplatinum (II) (cisplatin) platinum widely used clinical setting front line against various neplasias particular testicular, ovarian, bladder head neck cancers.