Clinical Experience with Cisplatin and Carboplatin

摘要: Malignant disease is a major cause of mortality, killing approximately 25% individuals in the Western world. The most common cancers are those originating lung, breast, colon, and rectum (1). Improvements curability survival dependent on advances early detection, surgery, radiotherapy, chemotherapy, but once widespread metastatic has become established chemotherapy central component management. era commenced late 1940s 1950s with clinical introduction classical alkylating agents (e.g., nitrogen mustard, cyclophosphamide melphalan), antimetabolites [e.g., methotrexate 5-fluorouracil (5-FU)], marked improvement treatment lymphomas leukemias. next advance was appearance cisplatin 1972. Over last 25 years use its less toxic analog carboplatin influenced chemotherapeutic management many solid tumors. As result, germ cell tumors now curable (Fig. 1), outlook for patients ovarian cancer certain childhood improved significantly.