Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis.
作者： Qun Lin , Jian-Yong Cai , Chuan Lu , Jun Sun , Hua-Jun Ba
DOI: 10.1016/J.CCA.2017.07.016
关键词:
摘要: Abstract Background Intracerebral hemorrhage (ICH) pathophysiology involves inflammation. Macrophage migration inhibition factor (MIF), a pro-inflammatory cytokine, is related to prognosis of ischemic stroke. The aim this study was investigate whether serum MIF levels are associated with severity and outcomes in patients acute ICH. Methods We enrolled total 120 consecutive ICH healthy controls sampled blood on admission at entry respectively. Enzyme-linked immunosorbent assay used quantify levels. Results Serum were higher compared correlated hematoma volume, National Institutes Health Stroke Scale (NIHSS) scores plasma C-reactive protein After adjusting for other significant outcome predictors, an independent predictor 6-month overall survival unfavorable (modified Rankin score > 2). Areas under receiver-operating characteristic curve (ROC) levels, volume NIHSS similar outcome. Moreover, significantly improved areas ROC scores. Conclusions might be potential biomarker reflecting inflammation, patients.
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