The role of neurotrophins in the developing nervous system

摘要: Neurotrophins were originally identified by their ability to promote the survival of developing neurons. However, recent work on these proteins indicates that they may also influence proliferation and differentiation neuron progenitor cells regulate several differentiated traits neurons throughout life. Moreover, effects neurotrophins have turned out be more complex than thought. Some switch requirements from one set another during development, involved in regulating a population at any time. Much our understanding developmental physiology has come studying peripheral nervous system. Because progenitors are segregated into anatomically discrete sites, it been possible obtain for vitro experimental studies earliest stage development. The generation mice having null mutations neurotrophin receptor genes opened up an unparalleled opportunity assess physiological relevance wealth data obtained studies. Here I provide chronological account members NGF family neural lineage with special reference