Use of antimicrobial growth promoters in food animals and Enterococcus faecium resistance to therapeutic antimicrobial drugs in Europe.

摘要: Supplementing animal feed with antimicrobial agents to enhance growth has been common practice for more than 30 years and is estimated constitute half the total use worldwide. The potential public health consequences of this have debated; however, until recently, clear evidence a risk was not available. Accumulating now indicates that glycopeptide avoparcin as promoter created in food animals major reservoir Enterococcus faecium, which contains high level resistance determinant vanA, located on Tn1546 transposon. Furthermore, glycopeptide-resistant strains, well determinants, can be transmitted from humans. Two classes expected provide future therapeutic options treatment infections vancomycin-resistant enterococci analogues among promoters, huge resistant E. faecium already created, posing new problem.