Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells.

摘要: The authors have demonstrated that human interleukin-4 (IL-4) induces increased expression of the mRNA encoding monocyte-specific chemoattractant and activator, MCP-1/JE, in endothelial cells (EC). In addition, treatment ECs with IL-4 resulted synthesis secretion MCP-1/JE protein. While did not significantly influence induced by interleukin-1 (IL-1) or tumor necrosis factor, concomitant IL-1 caused more protein than either cytokine alone. These results suggest EC-produced may mediate some IL-4's effects on monocyte physiology vivo, including anti-tumor properties.