New Interventional Treatment Model for Pancreatic Neoplasms Using Gemcitabine-Eluting Hydrogel Devices: In Vitro and In Vivo Results.
作者： Ruben Lopez-Benitez , David Benz , Yue Wu , Xinping Wu , Samuel Chen
DOI: 10.1007/S00270-017-1627-Z
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摘要: Objectives In vitro and in vivo evaluation of fast-and slow-release gemcitabine-eluting hydrogel (GEH) devices. Methods For in vitro elution, the GEH devices were placed in phosphate-buffered saline at 37° C. Periodically, the solution was analyzed for gemcitabine. The devices consisting of fast release (n= 8), slow release (n= 6), or bland (n= 4) were delivered through a 5-Fr catheter into the gastroduodenal artery of a pig. Additionally, four pigs were treated with intravenous (IV) injection of gemcitabine. Pigs were killed at day 1 (n …
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