Control of Aspirin Effect in Chronic Cardiovascular Patients Using two Whole Blood Platelet Function Assays: PFA-100 and Multiple Electrode Aggregometry
作者： K. -W. von Pape , M. Dzijan-Horn , J. Bohner , M. Spannagl , H. Weisser
DOI: 10.1007/978-3-540-36715-4_49
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摘要: In dieser Studie wurden zwei Methoden evaluiert und verglichen, welche die Wirkung von Azetylsalizylsaure (ASS) auf Thrombozytenaggregation im Vollblut erfassen. Die In-vitro-Blutungszeit wurde PFA-100 (Dade Behring, Marburg) mit der Kollagen/Adrenalin-Messzelle Zitratblut bestimmt. Vollblutaggregation am Multiplate- System (Dynabyte medical, Munchen) Hirudinblut (25 μg/ml) Zur Aggregation Induktoren Arachidonsaure (ASPItest), Kollagen (COLtest) sowie TRAP-6 (thrombin receptor activating peptide, TRAPtest) eingesetzt. Nach Aufklarung Einwilligung zur Analyse Vollblutaggregometrie 76 Patienten koronarer Herzkrankheit, unter langfristiger Azetylsalizylsaure- Behandlung standen (ASS-Patienten), entnommen. Zusatzlich 57 gesunden Blutspendern fur Im betrugen Verschlusszeiten ASS-Patienten 273 ± 49 s. Basierend dem Grenzwert (cut-off) 170 s bei 5 kein Ansprechen des Tests ASS-Therapie nachgewiesen (Aspirin-Non-Response). war den Vergleich (vs. AUC-Werte) zu in TRAPtest vergleichbar, hingegen COLtest ASPItest signifikant vermindert (p
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