Reduced aspirin responsiveness as assessed by impedance aggregometry is not associated with adverse outcome after cardiac surgery in a small low-risk cohort

摘要: Reduced aspirin responsiveness (i.e. persistent high platelet reactivity in function testing) might be associated with increased risk of myocardial ischemia and cardiac mortality patients coronary disease. However, the impact undergoing artery bypass grafting (CABG) is unclear. The aim this prospective cohort study was to evaluate predictive value reduced on thromboembolic events elective isolated CABG surgery intake until at least two days before surgery. We included 304 single-center study. Impedance aggregometry (Multiplate®) performed directly first day after defined as area under curve ASPItest (AUCASPI) ≥300 U. primary outcome a composite all-cause and/or major adverse or within 1 year. found 13 24% pre postoperatively, respectively. There no difference outcomes between normal preoperative measurement (log-rank test, p = 0.540). Multivariate analysis including logistic EuroSCORE I postoperative troponin T levels did not show any association (hazard ratio, 0.576; (95% CI 0.128-2.585; 0.471). Similarly, events. To conclude, evaluated by Multiplate® analyzer incidence