Supercritical CO2 foamed polycaprolactone scaffolds for controlled delivery of 5-fluorouracil, nicotinamide and triflusal.
作者： Aurelio Salerno , Javier Saurina , Concepción Domingo
DOI: 10.1016/J.IJPHARM.2015.11.012
关键词:
摘要: The manufacture of porous polycaprolactone (PCL) scaffolds containing three different drugs, namely 5-fluorouracil, nicotinamide and triflusal, was investigated in this work with the aim obtaining bioactive systems controlled drug delivery capabilities. were prepared by means a supercritical CO2 (scCO2) foaming technique optimizing loading process. This achieved dissolving drugs organic solvents miscible scCO2 mixing these drug/solvent solutions PCL powder. as mixtures further compressed to eliminate air bubbles finally processed technique. ScCO2 saturation conditions optimized create porosity within samples allow for concomitant removal solvents. Physical chemical properties scaffolds, well content profiles, studied HPLC. results study demonstrated that composition starting PCL/drug/solvent affected polymer crystallization, scaffold morphology pore structure features. Furthermore, it found efficiency depended on both initial solution solubility scCO2. Nevertheless, case highly scCO2-soluble such improved adding proper amount free inside pressure vessel. indicated release profiles mainly upon
sci-hub.se 参考文章(45)
Thomas R. Sharp, John F. Ward, John E. Byfield, Paula M. Calabro-Jones, Time-dose relationships for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro. Cancer Research. ,vol. 42, pp. 4413- 4420 ,(1982)
Kwangsok Kim, Yen K Luu, Charles Chang, Dufei Fang, Benjamin S Hsiao, Benjamin Chu, Michael Hadjiargyrou, None, Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds Journal of Controlled Release. ,vol. 98, pp. 47- 56 ,(2004) , 10.1016/J.JCONREL.2004.04.009
Aurelio Salerno, Concepción Domingo, A novel bio-safe phase separation process for preparing open-pore biodegradable polycaprolactone microparticles. Materials Science and Engineering: C. ,vol. 42, pp. 102- 110 ,(2014) , 10.1016/J.MSEC.2014.05.037
C. Bordes, V. Fréville, E. Ruffin, P. Marote, J.Y. Gauvrit, S. Briançon, P. Lantéri, Determination of poly(ɛ-caprolactone) solubility parameters: Application to solvent substitution in a microencapsulation process International Journal of Pharmaceutics. ,vol. 383, pp. 236- 243 ,(2010) , 10.1016/J.IJPHARM.2009.09.023
Wendy S Koegler, Carmen Patrick, Michael J Cima, Linda G Griffith, None, Carbon dioxide extraction of residual chloroform from biodegradable polymers. Journal of Biomedical Materials Research. ,vol. 63, pp. 567- 576 ,(2002) , 10.1002/JBM.10209
Claudia Fischbach, Ruth Chen, Takuya Matsumoto, Tobias Schmelzle, Joan S Brugge, Peter J Polverini, David J Mooney, Engineering tumors with 3D scaffolds. Nature Methods. ,vol. 4, pp. 855- 860 ,(2007) , 10.1038/NMETH1085
Francesca Ungaro, Marco Biondi, Ivana d'Angelo, Laura Indolfi, Fabiana Quaglia, Paolo Antonio Netti, Maria Immacolata La Rotonda, Microsphere-integrated collagen scaffolds for tissue engineering: Effect of microsphere formulation and scaffold properties on protein release kinetics Journal of Controlled Release. ,vol. 113, pp. 128- 136 ,(2006) , 10.1016/J.JCONREL.2006.04.011
Maria Ann Woodruff, Dietmar Werner Hutmacher, The return of a forgotten polymer—Polycaprolactone in the 21st century Progress in Polymer Science. ,vol. 35, pp. 1217- 1256 ,(2010) , 10.1016/J.PROGPOLYMSCI.2010.04.002
Anna Argemí, Ana López-Periago, Concepción Domingo, Javier Saurina, Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies Journal of Pharmaceutical and Biomedical Analysis. ,vol. 46, pp. 456- 462 ,(2008) , 10.1016/J.JPBA.2007.11.005
Owen R. Davies, Andrew L. Lewis, Martin J. Whitaker, Hongyun Tai, Kevin M. Shakesheff, Steven M. Howdle, Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue engineering Advanced Drug Delivery Reviews. ,vol. 60, pp. 373- 387 ,(2008) , 10.1016/J.ADDR.2006.12.001