The use of human neurons for novel drug discovery in dementia research

摘要: ABSTRACTIntroduction: Although many disease models exist for neurodegenerative disease, the translation of basic research findings to clinic is very limited. Studies using freshly resected human brain tissue, commonly discarded from neurosurgical procedures, should complement on-going work stem cell-derived neurons and glia thus increasing likelihood success in clinical trials.Areas covered: Herein, authors discuss key issues lack clinic. They also review evidence that neurons, both tissue such as induced pluripotent cells (iPSCs), can be used analysis physiological molecular mechanisms health disease. Furthermore, compare contrast studies live neuron models. Using an example area neurodegeneration, suggest replicating elements rese...