Studies on experimental aspergillosis in immunodeficient mice.

摘要: Abstract Mice with either chemically suppressed immune response or specifically induced T cell B immunodeficienty were challenged Aspergillus fumigatus spores. Chemical immunosuppressants used cortisone, cyclophosphamide silica. deficiency was produced by thymectomy and ALS administration, whereas, administration of anti-mouse IgM antibodies in newborn mice. The susceptibility such animals to A. challenge monitored mortality pattern demonstration dissemination fungus different organs. cortisone silica made mice highly susceptible infection, initially lowered host's resistance but later had little effect. also did not differ significantly from normal animals. Similarly passive transfer specific enhance the protection host experimental aspergillosis. However, cells macrophages alone combination results provide evidence that play essential role immunity murine Whereas, even does alter much