Reactivity of potential anti-diabetic molybdenum(VI) complexes in biological media: A XANES spectroscopic study

摘要: The application of Mo(VI) complexes as anti-diabetic agents is a subject considerable recent interest. stability and speciation [Mo(VI)O(4)](2-) three analogs known V(IV) ([Mo(VI)O(2)L(2)]; where LH=2,4-pentanedione, l-cysteine ethyl ester or N,N-diethyldithiocarbamic acid) in natural simulated biological fluids (including blood its components, cell culture media, artificial digestion systems) were studied using MoK-edge XANES (X-ray absorption near-edge structure) spectroscopy freeze-dried samples at 20K. All the [MoO(2)L(2)] decomposed extensively under gastric intestinal conditions (3 h 310 K), well plasma medium (24 K). reaction products [MoO(4)](2-) with could be satisfactorily modelled (using multiple linear regression analyses) mixtures tetrahedral octahedral species (with O-donor ligands) various ratios, which dependent on nature rather than that initial compounds. Red cells take up predominantly form [MoO(4)](2-). Implications these results to development Mo(VI)-based anti-diabetics mechanisms uptake metabolism are discussed.