Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer.
作者： Vid Leko , Lucas A. McDuffie , Zhili Zheng , Jared J. Gartner , Todd D. Prickett
关键词:
摘要: Immune checkpoint inhibitors are effective in treating a variety of malignancies, including metastatic bladder cancer. A generally accepted hypothesis suggests that immune induce tumor regressions by reactivating population endogenous tumor-infiltrating lymphocytes (TILs) recognize cancer neoantigens. Although previous studies have identified neoantigen-reactive TILs from several types cancer, no study to date has shown whether can be found tumors. To address this, we generated TIL cultures patients with primary and tested their ability tumor-specific mutations. We CD4+ one patient recognized mutated C-terminal binding protein 1 an MHC class II-restricted manner. This finding reside which may help explain the effectiveness blockade this disease also provides rationale for future use adoptive T cell therapy targeting neoantigens
sci-hub.se 参考文章(65)
Maryse Guéguen, Jean-Jacques Patard, Béatrice Gaugler, Francis Brasseur, Jean-Christophe Renauld, Paul J Van Cangh, Thierry Boon, Benoı̂t J Van den Eynde, None, An Antigen Recognized by Autologous CTLs on a Human Bladder Carcinoma Journal of Immunology. ,vol. 160, pp. 6188- 6194 ,(1998)
Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596
Gil Redelman-Sidi, Michael S. Glickman, Bernard H. Bochner, The mechanism of action of BCG therapy for bladder cancer—a current perspective Nature Reviews Urology. ,vol. 11, pp. 153- 162 ,(2014) , 10.1038/NRUROL.2014.15
Xavier Langa, Elena López-Knowles, José A Lorente, Josep Lloreta, David G Pisano, Laia Richart, Daniel Rico, Rocío N Salgado, Adonina Tardón, Stephen Chanock, Simon Heath, Alfonso Valencia, Ana Losada, Ivo Gut, Núria Malats, Francisco X Real, Cristina Balbás-Martínez, Ana Sagrera, Enrique Carrillo-de-Santa-Pau, Julie Earl, Mirari Márquez, Miguel Vazquez, Eleonora Lapi, Francesc Castro-Giner, Sergi Beltran, Mònica Bayés, Alfredo Carrato, Juan C Cigudosa, Orlando Domínguez, Marta Gut, Jesús Herranz, Núria Juanpere, Manolis Kogevinas, Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nature Genetics. ,vol. 45, pp. 1464- 1469 ,(2013) , 10.1038/NG.2799
I. Levin, T. Klein, J. Goldstein, O. Kuperman, J. Kanetti, B. Klein, Expression of class I histocompatibility antigens in transitional cell carcinoma of the urinary bladder in relation to survival Cancer. ,vol. 68, pp. 2591- 2594 ,(1991) , 10.1002/1097-0142(19911215)68:12<2591::AID-CNCR2820681212>3.0.CO;2-L
J-B Cazier, SR Rao, CM McLean, AK Walker, BJ Wright, EEM Jaeger, C Kartsonaki, L Marsden, C Yau, C Camps, P Kaisaki, Christopher Allan, Moustafa Attar, John Bell, David Bentley, John Broxholme, David Buck, Jean-Baptiste Cazier, Richard Copley, Richard Cornall, Peter Donnelly, Simon Fiddy, Angie Green, Lorna Gregory, Russell Grocock, Edouard Hatton, Chris Holmes, Linda Hughes, Peter Humburg, Sean Humphray, Alexander Kanapin, Zoya Kingsbury, Julian Knight, Sarah Lamble, Stefano Lise, Lorne Lonie, Gerton Lunter, Hilary Martin, Lisa Murray, Davis McCarthy, Gil McVean, Alistair Pagnamenta, Paolo Piazza, Guadelupe Polanco, Peter Ratcliffe, Andy Rimmer, Natasha Sahgal, Jenny Taylor, Ian Tomlinson, Amy Trebes, Andrew Wilkie, Ben Wright, Chris Yau, J Taylor, JW Catto, IPM Tomlinson, AE Kiltie, FC Hamdy, Oxford-Illumina WGS500 Consortium, Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden Nature Communications. ,vol. 5, pp. 3756- 3756 ,(2014) , 10.1038/NCOMMS4756
Isabel Maleno, Natalia Aptsiauri, Teresa Cabrera, Aurelia Gallego, Annette Paschen, Miguel Angel López-Nevot, Federico Garrido, Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors Immunogenetics. ,vol. 63, pp. 65- 71 ,(2011) , 10.1007/S00251-010-0494-4
Pawel Muranski, Andrea Boni, Paul A. Antony, Lydie Cassard, Kari R. Irvine, Andrew Kaiser, Chrystal M. Paulos, Douglas C. Palmer, Christopher E. Touloukian, Krzysztof Ptak, Luca Gattinoni, Claudia Wrzesinski, Christian S. Hinrichs, Keith W. Kerstann, Lionel Feigenbaum, Chi-Chao Chan, Nicholas P. Restifo, Tumor-specific Th17-polarized cells eradicate large established melanoma Blood. ,vol. 112, pp. 362- 373 ,(2008) , 10.1182/BLOOD-2007-11-120998
Michael S Lawrence, Petar Stojanov, Paz Polak, Gregory V Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L Carter, Chip Stewart, Craig H Mermel, Steven A Roberts, Adam Kiezun, Peter S Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H Ramos, Trevor J Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein, David I Heiman, Timothy Fennell, Marcin Imielinski, Bryan Hernandez, Eran Hodis, Sylvan Baca, Austin M Dulak, Jens Lohr, Dan-Avi Landau, Catherine J Wu, Jorge Melendez-Zajgla, Alfredo Hidalgo-Miranda, Amnon Koren, Steven A McCarroll, Jaume Mora, Ryan S Lee, Brian Crompton, Robert Onofrio, Melissa Parkin, Wendy Winckler, Kristin Ardlie, Stacey B Gabriel, Charles WM Roberts, Jaclyn A Biegel, Kimberly Stegmaier, Adam J Bass, Levi A Garraway, Matthew Meyerson, Todd R Golub, Dmitry A Gordenin, Shamil Sunyaev, Eric S Lander, Gad Getz, None, Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature. ,vol. 499, pp. 214- 218 ,(2013) , 10.1038/NATURE12213
Ton N. Schumacher, Robert D. Schreiber, Neoantigens in cancer immunotherapy Science. ,vol. 348, pp. 69- 74 ,(2015) , 10.1126/SCIENCE.AAA4971